This webpage contains reference information only. We are unable to provide advice on personal medical matters. Please contact your doctor or other relevant healthcare professional for specific, health-related advice and support.

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Focused on the Cure

Find out more about Cell Therapy

What is CAR T-cell therapy?

Chimeric antigen receptor (CAR) T-cell therapy is an individualised treatment where T cells (type of white blood cell) are removed from a patient and modified so they can recognise and target cancer cells. The engineered cells are then returned to the same patient.

 

Step 1

Collect

patient’s white blood cells

Step 2

Isolate

and activate the T-cells

Step 3

Engineer

the T-cells with a chimeric antigen receptor (CAR) gene

Step 4

Grow

and expand the number of T-cells

Step 5

Infuse

the same patient with engineered T-cells

Patient eligibility

Who is CAR T treatment for?

CAR T-cell therapy is a specialised treatment option for patients with specific difficult-to-treat
blood cancers who do not respond to (refractory) or fail (relapsed) initial treatment. Patients
should speak to their doctor or other relevant healthcare for specific, health-related
advice and support.

CAR T-cell therapy has been studied in patients with a range of blood cancers, including diffuse
large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma (PMBCL), high-grade
B-cell lymphoma (HGBL), acute lymphoblastic leukaemia (ALL), follicular lymphoma (FL), mantle
cell lymphoma (MCL) and multiple myeloma (MM).

Given its complex process, CAR T-cell therapy must be administered at a qualified treatment
centre where healthcare professionals have undergone a rigorous training process.

How does CAR T-cell therapy work?

The mechanism of action of CAR T-cell therapy

CAR T-cell therapy is an individualised treatment that is changing the way cancer is treated. Cell therapy technology uses the power of a patient's own immune system to attack certain types of cancer cells.

Events and Congress

Click here to learn more about Gilead and Kite's presence at the events and congresses including the latest abstracts and posters.

Learn more

Patient Videos

 

Coming soon.

Resources

The links below provide reference information on Gilead and Kite’s cell therapy products, including the Summary of Product Characteristics (SmPC) and the Patient Information Leaflet (PIL).

  This medicine is subject to additional monitoring. This will allow quick identification of new safety information. You can help by reporting any side effects you may get.

Reporting of side effects 
If you get any side effects, talk to your doctor or nurse. In the United Kingdom, you can also report side effects directly via the Yellow Card Scheme, Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. You can also report side effects and quality complaints to Gilead. For information now how to report a side effect in another country, click here. By reporting side effects, you can help provide more information on the safety of this medicine.

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